Panama is really nice place to live. It’s got diverse landscapes, including luxurious beaches, rolling mountains, and deep rainforests. The weather is temperate enough to be out in nature all year long, but don’t forget the enticements of the capital, Panama City. For Americans, this is an especially easy move as the US dollar is the official currency.
If you want to work in Panama long term, there are several flexible options to explore. People who hail from one of 50 “Friendly Nations” can pretty much go and get right to work (provided they can find someone to hire them). There are other pathways to a Panamanian work visa that are largely skills based, and it’s an extensive enough program that you are likely to find a way to qualify.